منابع مشابه
Human pathogens and the host cell SUMOylation system.
Since posttranslational modification (PTM) by the small ubiquitin-related modifiers (SUMOs) was discovered over a decade ago, a huge number of cellular proteins have been found to be reversibly modified, resulting in alteration of differential cellular pathways. Although the molecular consequences of SUMO attachment are difficult to predict, the underlying principle of SUMOylation is altering i...
متن کاملHost-Tumor Interactions.
In 1889, Paget asked, "What is it that decides what organs shall suffer in a case of disseminated cancer?" Paget’s study was motivated by the discrepancy between consideration of blood flow and the frequency of metastases in different organs. After examining the autopsy records of 735 women who died of breast cancer and many other patients with different neoplasms, he concluded that metastases ...
متن کاملEFFECT OF TOXOCARA CANIS SECOND STAGE LARVAE ON THE HOST IMMUNE SYSTEM
We have studied functional alteration of immunocytes in mice following inoculation of Toxocara canis second stage larvae. Results indicated depression of lymphocyte blastogenesis in response to concanavalin-A, phytohemagglutinin and allogeneic non B-cells; however, B-cell polyclonal activation was not affected as indicated by the production of total IgG. In contrast, frequency of antibody ...
متن کامل“pioneering the Xenopus Oocyte and Egg System”
A “Reflections” article provides an opportunity to focus on key findings during a career from a personal and historical perspective. As a graduate student in the late 1960’s at Berkeley, I was introduced to the Xenopus oocyte by John Gerhart, who shared his fascination with the work of John Gurdon that had pointed out the unique and powerful features of the oocyte and egg,, particularly the abi...
متن کاملThe Effect of Herpes Simplex Virus Virion Host Shutoff Gene- a New Suicide Gene- on Tumor Cells
Background: The herpes simplex virus (HSV) UL41 gene product, virion host shutoff (Vhs) protein, mediates the rapid degradation of both viral and cellular mRNA. This ability suggests that Vhs protein can be used as a suicide gene in cancer gene therapy applications. The recent reports have shown that the degradation of cellular mRNA during herpes simplex infection is selective. RNA containing A...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1970
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.23.305